Home | Contact Us
SYNOPSIS OF AH&DMRT ROUND SIX RESEARCH GRANT #1

"DOES HYPERBARIC OXYGEN THERAPY LEAD TO A SUSTAINED INCREASE IN INSULIN SENSITIVITY?"

Principal Investigator 

Dr David Wilkinson,
Medical Director,
Hyperbaric Medicine Unit,
Royal Adelaide Hospital,
North Terrace,
Adelaide, SA 5000
AUSTRALIA
Email: david.wilkinson@health.sa.gov.au
Phone: +61 8 8222 5116
Fax: +61 8 8232 4207

Other Investigators

Prof Ian Chapman PhD
Discipline of Medicine
University of Adelaide

Assoc Prof Leonie Heilbronn PhD
Discipline of Medicine
University of Adelaide

The project will be conducted at the Hyperbaric Medicine Unit, Royal Adelaide Hospital.

Hypothesis and Aims

Hypothesis: Insulin sensitivity will be increased when testing is initiated after exit from the chamber (at 2-hours post HBOT), and that this effect will be apparent after 3 treatments.

Aims:
  1. To determine whether the insulin sensitising effect of HBOT is apparent upon exit from the hyperbaric chamber.
  2. 2To examine mechanisms underpinning the increase in insulin sensitivity following HBOT.

Outcomes and significance

Outcomes:

This study will provide new knowledge about the importance of adequate oxygen delivery to adipose tissue in modulating obesity-associated insulin resistance in humans. Specifically we are testing if the increase in insulin sensitivity is still present 2 hours after exit from the chamber (by hyperinsulinaemic euglycaemic clamp), and also if there is evidence of the effect at 24-hours (by Oral Glucose Tolerance Test). At the same time, we will extend our previous investigation of inflammatory cytokines, by further investigation of blood and adipose tissue biomarkers which may help identify the mechanism of this effect.

Significance:

The prevalence of obesity is rapidly escalating and is tightly linked with insulin resistance, which underpins the development of type 2 diabetes (T2DM) and cardiovascular disease. The precise mechanisms of insulin resistance in humans are unclear, but localized adipose tissue hypoxia may contribute to this development. In published and as-yet unpublished work, we have shown that HBOT can significantly increase insulin sensitivity in overweight and obese men, with and without T2DM. An understanding of how this effect works and how long it lasts for may have direct relevance to the management of important medical conditions such as T2DM or perhaps in influencing its development.







Areas of Specialty
    Site Map | Privacy Statement |
 
Copyright 2017    Australasian Hyperbaric & Diving Medicine Research Trust
   Website by Michael Vaney Marketing